Fresh analysis indicates that individuals who come off blockbuster slimming jabs like Mounjaro or Wegovy may regain lost weight at a significantly accelerated pace than those who stop traditional diet and exercise regimens.
Findings released in a leading health publication shows that while obese individuals often shed substantial amounts of their total mass while undergoing treatment, the weight comes back at an estimated rate of nearly a kilo each month once they quit.
"Individuals buying such drugs should be aware of the potential of fast rebound weight gain when the medication is stopped," cautioned researcher Dr. Susan Jebb.
This pace of regain suggests a reversion to starting weight within about 18 months.
Comparing Therapies
The analysis, which looked at 37 of studies involving over 9,000 of patients, compared the results of the injectable medications with other pills.
Scientists point out that people who shed pounds through dieting usually see a slower weight regain—approximately 0.1 kg a month—once they finish.
The Reason for the Rapid Rebound
Experts propose the way of the jabs is key to understanding the heightened regain.
The injections copy a natural hormone called GLP-1, which controls hunger.
"Long-term administration of the hormone levels far above than the body's typical production may cause the system to produce less of its endogenous GLP-1, and may also lessen sensitivity to its actions," explained Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement leads to appetite is unsuppressed, making excessive eating much more probable."
A Chronic Condition?
The NHS suggest the jabs for individuals with weight-linked medical conditions, alongside recommended diet and exercise modifications.
Many experts argue that, considering the high risk of relapse, the therapy should be considered life-long.
This perspective is echoed by drug manufacturers, who state that the findings "emphasize the chronic nature of obesity," comparing it to managing conditions like high blood pressure.
User Experiences
People who have come off the medication explain a intense resurgence of cravings.
"I experienced a trigger flipping and you become extremely hungry," described an individual.
This challenge is compounded if users have not adopted permanent dietary or behavioural changes during treatment.
Widespread Interest
Figures indicate that millions of adults in the UK have tried these injections in the past year, with interest remaining high.
- Use is more common among women compared to males.
- The middle-aged demographic shows the highest usage rates.
- Many access the medications through private healthcare rather than public health services.
Ultimately, experts caution that while these medications are potent tools for shedding pounds, they are not a permanent fix and long-term success likely depends on integrated lifestyle changes.
